Potensi Daun Kenikir (Cosmos caudatus Kunth) Sebagai Imunostimulan pada Akuakultur: Kajian Literatur
DOI:
https://doi.org/10.61761/agiotech.3.1.21-27Keywords:
Ulam raja, Imunostimulan, Fitofarmaka, AkuakulturAbstract
Intensifikasi akuakultur sering kali diikuti dengan peningkatan stres dan kerentanan organisme budidaya terhadap penyakit, sehingga penggunaan antibiotik sintetis menjadi praktik umum. Namun, penggunaan secara berlebihan menimbulkan berbagai permasalahan, seperti resistensi bakteri, residu pada produk perikanan, dan dampak negatif terhadap lingkungan. Oleh karena itu, diperlukan alternatif pengendalian penyakit yang lebih aman dan berkelanjutan, salah satunya melalui pemanfaatan fitofarmaka. Daun kenikir (Cosmos caudatus Kunth) merupakan tanaman yang diketahui mengandung berbagai senyawa bioaktif, seperti flavonoid, fenolik, saponin, tanin, dan alkaloid, yang berpotensi sebagai imunostimulan alami. Kajian ini bertujuan untuk menelaah potensi daun kenikir sebagai imunostimulan dalam akuakultur berdasarkan studi-studi terdahulu. Metode yang digunakan adalah kajian literatur dengan mengumpulkan dan menganalisis hasil penelitian terkait kandungan fitokimia, aktivitas biologis, mekanisme kerja, serta aplikasi daun kenikir pada organisme akuakultur. Hasil kajian menunjukkan bahwa senyawa bioaktif daun kenikir memiliki aktivitas antioksidan, antibakteri, dan imunomodulator yang mampu meningkatkan respons imun nonspesifik, ketahanan terhadap penyakit, pertumbuhan, serta sintasan ikan dan udang budidaya. Dengan demikian, daun kenikir berpotensi dikembangkan sebagai alternatif fitofarmaka yang aman, efektif, dan ramah lingkungan untuk mendukung sistem akuakultur berkelanjutan, meskipun masih diperlukan penelitian lanjutan terkait dosis optimal, metode aplikasi, dan keamanan jangka panjang
References
Abidin, Z., Aminah, A., Razak, R., & Putri, A.Y.E. (2024). Penentuan Kadar Fenolik, Tanin, Flavonoid, dan Saponin Ekstrak Etanol Daun Kenikir (Cosmos caudatus Kunth.). Makassar Pharmaceutical Science Journal (MPSJ), 2(2): 344-355.
Adeshina, I., Tiamiyu, L.O., Abubakar, M.I., Ogundayomi, O.O., & Adesanmi, O. (2021). Effects of Dietary Mitracarpus scaber Leaves Extract on Growth, Physiological, Antioxidants, and Mucosal Immune Profiles of North African catfish, Clarias gariepinus, and Resistance Against Edwardsiella tarda Infection. Tropical Animal Health and Production, 53(6): 541.
Ahda, M., Jaswir, I., Khatib, A., Ahmed, Q.U., & Mohamad, S.N.A.S. (2023). A Review on Cosmos caudatus as A Potential Medicinal Plant based on Pharmacognosy, Phytochemistry, and Pharmacological Activities. International Journal of Food Properties, 26(1): 344–358.
Astuti, S.W., & Sasmito, E. (2024). Aktivitas Antioksidan Ekstrak Etanol 50% dan 70% Daun Kenikir (Cosmos caudatus Kunth) dengan Metode DPPH (2,2 Diphenyl-1 Picrylhydrazyl). Journal of Comprehensive Science (JCS), 3(9).
Au-Yeung, C., Tsui, Y.-L., Choi, M.-H., Chan, K.-W., Wong, S. F., Ling, Y., Lam, C., Lam, K.-L., & Mo, W. Y. (2025). Antibiotic Abuse in Ornamental Fish: An Overlooked Reservoir for Antibiotic Resistance. Microorganisms, 13(4): 937.
Cheng, S.-H., Barakatun-Nisak, M.Y., Anthony, J., & Ismail, A. (2015). Potential Medicinal Benefits of Cosmos caudatus (Ulam Raja): A scoping review. Journal of Research in Medical Sciences, 20(10), 1000–1006.
Effendi, I., Kurniawan, R., Windarti, W., Razman, M.R., Al-Harbi, A., Nasution, N.M., Syahputra, T., & Masjudi, H. (2025). The Optimal Dose of Phytoimmunostimulant for the Growth and Immunity of Carp (Cyprinus carpio L) in Brackish Water Infected with Aeromonas hydrophila. The Philippine Journal of Fisheries 32(2): 341-350.
Gundi, V.A.K.B., Bogireddy, D., Vundru, A.K., Arthala, P.K., Vadela, M.B., Karri, S., Allam, U.S., Gujjula, M.S., & Kodali, V.P. (2025). Microbial Pathogens in Aquaculture: A Review of Emerging Threats. Academia Biology, 3(3).
Hassan, S.A., Mijin, S., Yusoff, U.K., Ding, P., & Wahab, P.E.M. (2012). Nitrate, Ascorbic Acid, Mineral and Antioxidant Activities of Cosmos caudatus in Response to Organic and Mineral-Based Fertilizer Rates. Molecules, 17(7): 7843–7853.
Hastuti, S., Zubaidah, A., & Fatimah, S. (2024). Respons Kekebalan Bawaan Ikan Nila (Oreochromis niloticus) yang Diberi Pakan dengan Suplementasi Daun Alpukat (Parsea americana Mill). Jurnal Riset Akuakultur, 19(1): 15.
Idora, M.N., Ferry, M., Nik, W.W., & Jasnizat, S. (2015). Evaluation of Tannin from Rhizophora apiculata as Natural Antifouling Agents in Epoxy Paint for Marine Application. Progress in Organic Coatings, 81: 125-131.
Indriyani, L.K.D., Wrasiati, L.P., & Suhendra, L. (2021). Kandungan Senyawa Bioaktif Teh Herbal Daun Kenikir (Cosmos caudatus Kunth.) pada Perlakuan Suhu Pengeringan dan Ukuran Partikel. Jurnal Rekayasa dan Manajemen Agroindustri, 9(1).
Jana, P., Karmakar, S., Roy, U., Paul, M., Singh, A.K., & Bera, K.K. (2018). Phytobiotics in Aquaculture Health Management: A Review. Journal of Entomology and Zoology Studies, 6(4): 1422–1429.
Jannah, M., Wijaya, S., & Setiawan, H.K. (2021). Standarisasi Simplisia Daun Kenikir (Cosmos caudatus Kunth) dari Tiga Daerah Berbeda. Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice), 8(1): 13-20.
Javadi, N., Abas, F., Abdul Hamid, A., Simoh, S., Shaari, K., Ismail, I. S., Mediani, A., & Khatib, A. (2014). GC‐MS‐Based Metabolite Profiling of Cosmos caudatus Leaves Possessing Alpha‐Glucosidase Inhibitory Activity. Journal of Food Science, 79(6).
Kurniawan, R., Windarti, W., Effendi, I., Simarmata, A.H., Efawani, E., Firmansyah, R., Syuhada, N.I., Karsih, O.R. (2025). The Effectiveness of Cosmos caudatus in Preventing Hyperglycemia due to Aeromonas hydrophila Infection in Pangasianodon hypohthalmus. Asian Journal of Aquatic Sciences, 8(3): 319-326
Manage, P. M. (2018). Heavy Use of Antibiotics in Aquaculture: Emerging Human and Animal Health Problems – A Review. Sri Lanka Journal of Aquatic Sciences, 23(1), 13.
Masitah, M., Pribadi, T., Pratama, M.I., Harrist, R.F., Sari, P.A., Dianita, F., & Setiawan, V.K. (2023). Analisis Kandungan Metabolik Sekunder pada Daun Kenikir (Cosmos caudatus Kunth.) dengan Pelarut Metanol, Etanol, dan Etil Asetat. Bioedukasi, 14(2).
Masmor, E., Abidin, Z., & Razak, R. (2024). Analisis Kandungan Flavonoid Ekstrak Etanol Deklorofilasi Daun Kenikir (Cosmos caudatus). Makassar Pharmaceutical Science Journal, 1(4), 347–357.
Mateus, A.P., Power, D.M., & Canario, A.V.M. (2017). Stress and Disease in Fish (pp. 187–220). Academic Press.
Nusantari, C.S., & Zulaicha, A.S. (2024). Effect of Adding Kenikir Leaf Powder (Cosmos Caudatus Kunth) on the Protein Content of Functional Drinks based on Goat Milk Powder. Analit: Analytical and Environmental Chemistry, 1–10.
Rameli, N.M., Kader, M.A., Musa, N., Rahmah, S., Zaintathan, S., & Hong, O.C. (2021). Cosmos caudatus as a Dietary Supplement for Bagrid Catfish, Mystus nemurus. Songklanakarin J. Sci. Technol., 43(2): 575-581
Romadhoni, A., Subektim S., & Kismiyati, K. (2020). The Effect of Cosmos caudatus Extract on the Survival Rate of Litopenaeus vannamei Post Larvae Against Salinity. AACL Bioflux, 13(4):1820-1826.
Sahputri,H.K., Windarti, W., Efizon, D., Kurniawan, R., Karsih, O.R., & Putri, M.N. (2024) Hematological Response of Pangasianodon hypophthalmus Fed Cosmos caudatus Enriched Feed and Reared in Saline Media. Asian Journal of Aquatic Sciences, 8(1): 128-137
Samudra, S. R., Fitriadi, R., & Marhaeni, B. (2021). Antifouling-Bacterial Potentials of Kenikir (Cosmos caudatus) and Bandotan (Ageratum conyzoides) Leaf Extracts in Freshwater Environment. Journal of Aquaculture and Fish Health, 10(2): 213–220.
Simarmata, A.H., Windarti, W., Effendi, I. (2025). The Effectiveness of Cosmos caudatus Enriched Pellets to Improve Growth and Survival of Pangasianodon hypopthalmus Reared in Dark Saline Media. Egyptian Journal of Aquatic Biology & Fisheries, 29(3): 155-165
Susanti, N.L., Lestari, D.E., & Anwar, R. (2024). Ekstraksi dan Deteksi Fitokimia Kenikir (Cosmos caudatus Kunth.) Asal Panjang Utara, Lampung. AGRORADIX: Jurnal Ilmu Pertanian, 8(1): 113-120.
Syafitri, E., Afriani, D. T., Siregar, B., & Gustiawan, Y. (2020). Kandungan Fitokimia Dan Uji Aktivitas Antibakteria Ekstrak Daun. Jurnal Riset Akuakultur, 15(4), 253-259.
Syahidah, A., Saad, C.R., Daud, H.M., & Abdelhadi, Y.M. (2015). Status and Potential of herbal Applications in Aquaculture: A Review. Iranian Journal of Fisheries Sciences, 14(1): 27–44.
Thawabteh, A.M., Ghanem, A.W., Abu-Madi, S., Thaher, D., Jaghama, W., Karaman, R., Scrano, L., & Bufo, S.A. (2024). Antibacterial Activity and Antifungal Activity of Monomeric Alkaloids. Toxins, 16(11): 489.
Utami, Y.P., Imrawati, I., Ismail, I., Mus, S., Jariah, A., Mustarin, R., Lestari, W.O.D.A. & Waliulu, S. (2024). Optimisation of Phenolic Content and Antibacterial Activity of Cosmos caudatus Kunth. Leaf Ethanol Extract Using different Drying Techniques: Tropical Journal of Natural Product Research , 8(1): 5825-5831
Wan-Nadilah, W. A., Akhtar, M., Shaari, K., Khatib, A., Hamid, A.A., & Hamid, M. (2019). Variation in the Metabolites and Α-Glucosidase Inhibitory Activity of Cosmos caudatus at Different Growth Stages. BMC Complementary and Alternative Medicine, 19(1): 1–15.
Widyastuti, S., Badra, S., & Rahim, A. (2024). Efek Pemberian Ekstrak Daun Kenikir (Cosmos caudatus Kunth) terhadap Penurunan Kadar Asam Urat Darah Mencit (Mus musculus). Jurnal Farmasi, Kesehatan, dan Sains, 2(1), 103–111.
Windarti, W., Kurniawan, R. Effendi, I., Putri, M.N. & Riswan, M. (2025). Hematology and Health Status of Pangasianodon hypophthalmus Fed with Moringa oleifera Enriched Pellets and Infected with Aeromonas hydrophila. Egyptian Journal of Aquatic Biology & Fisheries, 29(4): 645-658
Yusof, M.N., Buyong, F., & Azmi, W.N.A.W. (2023). Antimicrobial Activity of Cosmos caudatus against Staphylococcus aureus and Escherichia coli. Journal of Advanced Research in Applied Sciences and Engineering Tehnology, 30(2): 272-281
Yusoff, N., Rukayadi, Y., Abas, F., Khatib, A., & Hassan, M. (2022). Application of Cosmos caudatus Kunth. (ulam raja) Extract as Antibacterial Agent in Beef and Shrimp Meats, and its Sensory Evaluation. International Food Research Journal, 29(4): 918–928
Yusoff, N.A.H., Rukayadi, Y., Abas, F., Khatib, A., & Hassan, M. (2024). Potential of Cosmos caudatus Kunth. Extract as Natural Food Sanitiser. International Food Research Journal, 31(3): 709–722.
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